Prohibitin-targeting peptide 1
Clinical data
Trade namesAdipotide
Other namesProhibitin-TP01; TP01
Legal status
Legal status
  • Investigational
Identifiers
CAS Number

Prohibitin-targeting peptide 1 (also known as prohibitin-TP01 and TP01; trade name Adipotide) is a peptidomimetic with sequence CKGGRAKDC-GG-D(KLAKLAK)2. It is an experimental proapoptotic drug[1] that has been shown to cause rapid weight loss in mice[2] and rhesus monkeys.[3] Its mechanism of action is to target specific blood vessels supplying adipose tissue with blood, cause the vessels to shrink and the fat cells fed by those vessels to undergo apoptosis.[4] TP01 is designed to bind to two receptors, ANXA2 and prohibitin, that are specific to blood vessels supplying white adipose tissue.[5]

As of 2019, clinical development has been discontinued.[6]

References

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  1. ^ "Prohibitin-targeting peptide 1". NCI Drug Dictionary. National Cancer Institutes. 2 February 2011.
  2. ^ Kolonin MG, Saha PK, Chan L, Pasqualini R, Arap W (June 2004). "Reversal of obesity by targeted ablation of adipose tissue". Nature Medicine. 10 (6). Nature Publishing Group: 625–32. doi:10.1038/nm1048. PMID 15133506. S2CID 19369938.
  3. ^ "Blood vessel mapping reveals four new 'ZIP codes'". medicalxpress. 24 October 2011. Retrieved 10 November 2011.
  4. ^ Barnhart KF, Christianson DR, Hanley PW, Driessen WH, Bernacky BJ, Baze WB, et al. (November 2011). "A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys". Science Translational Medicine. 3 (108): 108ra112. doi:10.1126/scitranslmed.3002621. PMC 3666164. PMID 22072637.
  5. ^ Staquicini FI, Cardó-Vila M, Kolonin MG, Trepel M, Edwards JK, Nunes DN, et al. (November 2011). "Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients". Proceedings of the National Academy of Sciences of the United States of America. 108 (46): 18637–42. Bibcode:2011PNAS..10818637S. doi:10.1073/pnas.1114503108. PMC 3219136. PMID 22049339.
  6. ^ "Prohibitin targeting peptide 1". Adis Insight. Springer Nature Switzerland AG.

📚 Artikel Terkait di Wikipedia

Prohibitin

Prohibitin, also known as PHB, is a protein that in humans is encoded by the PHB gene. The Phb gene has also been described in animals, fungi, plants,

PHB

Per-hop behaviour, in the DiffServ world Polyhydroxybutyrate, a biopolymer Prohibitin, a human gene Pedestrian hybrid beacon, a type of traffic signal Parnaíba-Prefeito

Retinoblastoma protein

activator inhibitor-2 Polymerase (DNA directed), alpha 1 PRDM2 PRKRA Prohibitin Promyelocytic leukemia protein RBBP4 RBBP7 RBBP8 RBBP9 SNAPC1 SKP2 SNAPC3

P53

Fusaro G, Dasgupta P, Rastogi S, Joshi B, Chellappan S (November 2003). "Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus

Matrix-assisted laser desorption/ionization

S2CID 17464318. Zhong, N.; Cui, Y.; Zhou, X.; Li, T.; Han, J. Identification of prohibitin 1 as a potential prognostic biomarker in human pancreatic carcinoma using

PHB2

Prohibitin-2 is a protein that in humans is encoded by the PHB2 gene. PHB2 has been shown to interact with PTMA. GRCh38: Ensembl release 89: ENSG00000215021

Lectin

Amir; Lagarda-Diaz, Irlanda (2022). "Characterization and expression of prohibitin during the mexican bean weevil (Zabrotes subfasciatus, Boheman, 1833)

Annexin A2

in anticoagulant reactions. Annexin A2 has been shown to interact with Prohibitin, CEACAM1, S100A10, PCNA, complement Factor H, and a number of viral factors