MELK 📖 Wikipedia

MELK
Struktur yang tersedia
PDB	Pencarian ortolog: PDBe RCSB
Daftar kode ID PDB
	4BKY, 4BKZ, 4D2P, 4D2T, 4D2V, 4D2W, 4IXP, 4UMP, 4UMQ, 4UMR, 4UMT, 4UMU, 5IHA, 5IHC, 5IH9, 5IH8
Pengidentifikasi
Alias	MELK, HPK38, maternal embryonic leucine zipper kinase
ID Eksternal	OMIM: 607025; MGI: 106924; HomoloGene: 32111; GeneCards: MELK; OMA:MELK - orthologs
Nomor EC	2.7.10.2
Lokasi gen (Manusia)
Kr.	Kromosom 9 (manusia)
Akhir	36,677,683 pb
Lokasi gen (Tikus)
Kr.	Kromosom 4 (tikus)
Akhir	44,364,675 pb
Pola ekspresi RNA
	Ekspresi tertinggi di
	secondary oocyte; ; ventricular zone; ; embrio; ; ganglionic eminence; ; Air ketuban; ; Gonad; ; Testis; ; gingival epithelium; ; Tulang kering; ; Tulang spongiosa;
	Ekspresi tertinggi di
	primitive streak; ; abdominal wall; ; primary oocyte; ; dermis; ; Ureter; ; endocardial cushion; ; maxillary prominence; ; medial ganglionic eminence; ; right lobe of liver; ; somite;
	Referensi data ekspresi selengkapnya
	Data ekspresi referensi lebih lanjut
Ontologi gen
Fungsi molekuler	transferase activity; nucleotide binding; calcium ion binding; protein kinase activity; non-membrane spanning protein tyrosine kinase activity; kinase activity; protein serine/threonine kinase activity; Ikatan protein plasma; ATP binding; lipid binding;
Komponen seluler	sitoplasma; membran; membran sel; cell cortex; Inti sel;
Proses biologis	intrinsic apoptotic signaling pathway in response to oxidative stress; hematapoises; intracellular signal transduction; Fosforilasi; protein phosphorylation; G2/M transition of mitotic cell cycle; neural precursor cell proliferation; positive regulation of apoptotic process; protein autophosphorylation; Siklus sel; cell population proliferation; Apoptosis; peptidyl-tyrosine phosphorylation;
	Sumber:Amigo / QuickGO
Ortologi
	9833
	17279
	ENSG00000165304
	ENSMUSG00000035683
	Q14680
	Q61846
NM_001256685; NM_001256687; NM_001256688; NM_001256689; NM_001256690;
	NM_001256691; NM_001256692; NM_001256693; NM_014791
	NM_010790
NP_001243614; NP_001243616; NP_001243617; NP_001243618; NP_001243619;
	NP_001243620; NP_001243621; NP_001243622; NP_055606
	NP_034920
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Maternal embryonic leucine zipper kinase (MELK) adalah enzim yang pada manusia disandi oleh gen MELK.^[5]^[6]^[7] MELK adalah serin/treonin kinase milik keluarga protein AMPK/snf1 kinase. MELK pertama kali diidentifikasi hadir sebagai mRNA maternal pada embrio tikus.^[8] MELK telah terbukti terlibat dalam perkembangan melalui siklus sel, mungkin terkait dengan interaksinya dengan CDC25B.^[9]

Ekspresi MELK meningkat pada sejumlah kanker dan merupakan target penelitian aktif untuk penghambatan farmakologis.^[10]

Interaksi

sunting

MELK telah terbukti berinteraksi dengan CDC25B.^[11]

Referensi

sunting

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165304 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035683 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 3 (1): 17–24. February 1996. doi:10.1093/dnares/3.1.17. PMID 8724849.
^ "New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo". Molecular Reproduction and Development. 47 (2): 148–56. June 1997. doi:10.1002/(SICI)1098-2795(199706)47:2<148::AID-MRD4>3.0.CO;2-M. PMID 9136115.
^ "Entrez Gene: MELK maternal embryonic leucine zipper kinase".
^ "Expression of Melk, a new protein kinase, during early mouse development". Developmental Dynamics. 215 (4): 344–51. August 1999. doi:10.1002/(SICI)1097-0177(199908)215:43.0.CO;2-H. PMID 10417823.
^ "Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation". The Journal of Cell Biology. 170 (3): 413–27. August 2005. doi:10.1083/jcb.200412115. PMC 2171475. PMID 16061694.
^ "Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers". Cancer Research. 65 (21): 9751–61. November 2005. doi:10.1158/0008-5472.CAN-04-4531. PMID 16266996.
^ "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene. 21 (50): 7630–41. October 2002. doi:10.1038/sj.onc.1205870. PMID 12400006.

Artikel bertopik enzim ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165304 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035683 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8724849-5] "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 3 (1): 17–24. February 1996. doi:10.1093/dnares/3.1.17. PMID 8724849.

[pmid9136115-6] "New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo". Molecular Reproduction and Development. 47 (2): 148–56. June 1997. doi:10.1002/(SICI)1098-2795(199706)47:2<148::AID-MRD4>3.0.CO;2-M. PMID 9136115.

[entrez-7] "Entrez Gene: MELK maternal embryonic leucine zipper kinase".

[8] "Expression of Melk, a new protein kinase, during early mouse development". Developmental Dynamics. 215 (4): 344–51. August 1999. doi:10.1002/(SICI)1097-0177(199908)215:43.0.CO;2-H. PMID 10417823.

[9] "Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation". The Journal of Cell Biology. 170 (3): 413–27. August 2005. doi:10.1083/jcb.200412115. PMC 2171475. PMID 16061694.

[10] "Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers". Cancer Research. 65 (21): 9751–61. November 2005. doi:10.1158/0008-5472.CAN-04-4531. PMID 16266996.

[pmid12400006-11] "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene. 21 (50): 7630–41. October 2002. doi:10.1038/sj.onc.1205870. PMID 12400006.

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MELK 📖 Wikipedia

Interaksi

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