ETF-Q oksidoreduktase 📖 Wikipedia

ETF-Q oksidoreduktase
Pengidentifikasi
Alias	ETFDH, electron-transferring-flavoprotein dehydrogenase, ETFQO, MADD, electron transfer flavoprotein dehydrogenase
ID Eksternal	OMIM: 231675; MGI: 106100; HomoloGene: 3275; GeneCards: ETFDH; OMA:ETFDH - orthologs
Lokasi gen (Manusia)
Kr.	Kromosom 4 (manusia)
Akhir	158,710,742 pb
Pola ekspresi RNA
	Ekspresi tertinggi di
	apex of heart; ; left ventricle; ; muscle of thigh; ; right lobe of liver; ; jejunal mucosa; ; right auricle of heart; ; right ventricle; ; Otot gastrocnemius; ; right adrenal gland; ; right adrenal cortex;
	Ekspresi tertinggi di
	right ventricle; ; myocardium of ventricle; ; Otot jantung; ; interventricular septum; ; cardiac muscle tissue of left ventricle; ; intercostal muscle; ; digastric muscle; ; soleus muscle; ; Diafragma; ; Jaringan adiposa cokelat;
	Referensi data ekspresi selengkapnya
	; ;
	Data ekspresi referensi lebih lanjut
Ontologi gen
Fungsi molekuler	4 iron, 4 sulfur cluster binding; ubiquinone binding; quinone binding; flavin adenine dinucleotide binding; iron-sulfur cluster binding; metal ion binding; electron transfer activity; oxidoreductase activity; electron-transferring-flavoprotein dehydrogenase activity; oxidoreductase activity, acting on metal ions, flavin as acceptor;
Komponen seluler	membran; integral component of mitochondrial inner membrane; mitochondrial matrix; mitokondria; mitochondrial inner membrane; mitochondrial membranes; mitochondrial electron transfer flavoprotein complex;
Proses biologis	fatty acid beta-oxidation using acyl-CoA dehydrogenase; response to oxidative stress; Rantai transpor elektron; respiratory electron transport chain;
	Sumber:Amigo / QuickGO
Ortologi
	2110
	66841
	ENSG00000171503
	ENSMUSG00000027809
	Q16134
	Q921G7
	NM_004453; NM_001281737; NM_001281738
	NM_025794
	NP_001268666; NP_001268667; NP_004444
	NP_080070
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Oksidoreduktase ETF-Q (bahasa Inggris: electron-transfer flavoprotein:ubiquinone oxidoreductase, electron-transferring-flavoprotein dehydrogenase, ETF-Q oxidoreductase, ETFQO, EC 1.5.5.1code: en is deprecated ) adalah enzim katalis berjenis flavoprotein 4Fe-4S,^[4] dengan berkas genetik ETFDH yang berperan dalam proses reduksi senyawa Q-1 dengan elektron dari senyawa flavoprotein ET, dan oksidasi asam lemak dan beberapa asam amino kemudian mentransfer elektronnya ke dalam rantai pernapasan mitokondria pada kompleks II.

ETF-QO diketemukan oleh Ruzicka dan Beinert pada tahun 1975, kemudian, diteliti lebih lanjut oleh Beckmann dan Frerman pada tahun 1985 sehingga karakter senyawa ini dapat diketahui.^[5] ETFQ merupakan komponen yang penting pada lintasa oksidasi asam lemak. Defisiensi ETF dan ETF-QO akan mengakibatkan kelainan metabolisme yang fatal yang disebut glutarikasiduria tipe II.

Rujukan

sunting

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171503 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ (Inggris) "Structure of electron transfer flavoprotein-ubiquinone oxidoreductase and electron transfer to the mitochondrial ubiquinone pool". Department of Biochemistry, Medical College of Wisconsin, Department of Pediatrics, University of Colorado Health Sciences Center, California Institute of Technology; Jian Zhang, Frank E. Frerman, Jung-Ja P. Kim dan Douglas C. Rees. Diakses tanggal 2010-11-11.
^ (Inggris) "Reactions of electron-transfer flavoprotein and electron-transfer flavoprotein: ubiquinone oxidoreductase". Department of Biochemistry and Biophysics, University of California, Molecular Biology Division, Veterans Administration Medical Center, Department of Chemical Pathology, University of Cape Town Medical School; Rona R. RAMSAY, Daniel J. STEENKAMP dan Mazhar HUSAIN. Diakses tanggal 2010-11-11.

Artikel bertopik biokimia ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171503 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] (Inggris) "Structure of electron transfer flavoprotein-ubiquinone oxidoreductase and electron transfer to the mitochondrial ubiquinone pool". Department of Biochemistry, Medical College of Wisconsin, Department of Pediatrics, University of Colorado Health Sciences Center, California Institute of Technology; Jian Zhang, Frank E. Frerman, Jung-Ja P. Kim dan Douglas C. Rees. Diakses tanggal 2010-11-11.

[5] (Inggris) "Reactions of electron-transfer flavoprotein and electron-transfer flavoprotein: ubiquinone oxidoreductase". Department of Biochemistry and Biophysics, University of California, Molecular Biology Division, Veterans Administration Medical Center, Department of Chemical Pathology, University of Cape Town Medical School; Rona R. RAMSAY, Daniel J. STEENKAMP dan Mazhar HUSAIN. Diakses tanggal 2010-11-11.

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ETF-Q oksidoreduktase 📖 Wikipedia

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