Dichlorophen
Ball-and-stick mode of the dichlorophen molecule
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 4-Chloro-2-[(5-chloro-2-hydroxyphenyl)methyl]phenol
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.002.335 Edit this at Wikidata
Chemical and physical data
FormulaC13H10Cl2O2
Molar mass269.12 g·mol−1
3D model (JSmol)
Density1.5 g/cm3 g/cm3
Melting point177.5 °C (351.5 °F)
Solubility in water0.003 g/100 mL[1] mg/mL (20 °C)
  • C1=CC(=C(C=C1Cl)CC2=C(C=CC(=C2)Cl)O)O
  • InChI=1S/C13H10Cl2O2/c14-10-1-3-12(16)8(6-10)5-9-7-11(15)2-4-13(9)17/h1-4,6-7,16-17H,5H2 ☒N
  • Key:MDNWOSOZYLHTCG-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Dichlorophen is an anticestodal agent, fungicide, germicide, and antimicrobial agent.[2] It is used in combination with toluene for the removal of parasites such as ascarids, hookworms, and tapeworms from dogs and cats.[3] In 2025, dichlorophen was reported to function as a tubulin binding mitotic inhibitor.[4]

Safety and regulation

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The LD50 (oral, mouse) is 3300 mg/kg.[5]

References

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  1. ^ Lide DR (1998). Handbook of Chemistry and Physics (87 ed.). Boca Raton, Florida: CRC Press. pp. 8–118. ISBN 0-8493-0594-2.
  2. ^ Milne, G.W.A. (Ed.). (2005). Gardner's commercially important chemicals: Synonyms, trade names, and properties. Hoboken, N.J.: Wiley-Interscience. Google Books
  3. ^ "Code of Federal Regulations", Code of Federal Regulations, Title 21, Volume 6, U.S. Government Printing Office, 2005-04-01, retrieved 2009-05-01
  4. ^ Baksheeva VE, La Rocca R, Allegro D, Derviaux C, Pasquier E, Roche P, Morelli X, Devred F, Golovin AV, Tsvetkov PO (2025). "NanoDSF Screening for Anti-tubulin Agents Uncovers New Structure–Activity Insights". Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.5c01008.
  5. ^ Fiege H, Voges HW, Hamamoto T, Umemura S, Iwata T, Miki H, Fujita Y, Buysch HJ, Garbe D, Paulus W (2007). "Phenol Derivatives". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a19_313. ISBN 978-3-527-30673-2.


📚 Artikel Terkait di Wikipedia

Moxidectin

Niclosamide# aminoacridine Quinacrine butyrophenone Desaspidin chlorophenol Dichlorophen Bunamidine Epsiprantel Antinematodal agents (including macrofilaricides)

List of fungicides

acid dicarboximide fungicides dichlobentiazox dichlofluanid dichlone dichlorophen dichlozoline [Wikidata] diclobutrazol [Wikidata] diclocymet [Wikidata]

Algaecide

paint Dichlone – quinone fungicide/algaecide, not persistent in soil Dichlorophen – also kills invertebrate animals and bacteria Diuron – herbicide/algaecide

Anticestodal agent

name from Cestoda. Examples include: albendazole albendazole sulfoxide dichlorophen niclosamide quinacrine Anticestodal+agents at the U.S. National Library

List of drugs: Df–Di

dicarbine (INN) dicarfen (INN) dichlorisone (INN) dichlormezanone (INN) dichlorophen (INN) dichlorophenarsine (INN) dichloroxylenol (INN) dichlorvos (INN)

ATC code P02

Bephenium P02CX03 Moxidectin P02DA01 Niclosamide P02DX01 Desaspidin P02DX02 Dichlorophen "ATC (Anatomical Therapeutic Chemical Classification System) – Synopsis"

List of MeSH codes (D02)

nordihydroguaiaretic acid MeSH D02.755.166.850 – tiron MeSH D02.755.190.270 – dichlorophen MeSH D02.755.190.350 – hexachlorophene MeSH D02.755.190.633 – pentachlorophenol