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C7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesC7, complement component 7, complement C7
External IDsOMIM: 217070; MGI: 88235; HomoloGene: 489; GeneCards: C7; OMA:C7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

730

109828

Ensembl

ENSG00000112936

ENSMUSG00000079105

UniProt

P10643

D3YXF5

RefSeq (mRNA)

NM_000587

NM_001243837

RefSeq (protein)

NP_000578

NP_001230766

Location (UCSC)Chr 5: 40.91 – 40.98 MbChr 15: 5.02 – 5.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Complement component 7 is a protein involved in the complement system of the innate immune system. C7 is part of the membrane attack complex (MAC) which creates a hole on pathogen surfaces, leading to cell lysis and death.

Its primary task is to bind the C5bC6 complex together. This junction alters the configuration of the protein molecules, exposing a hydrophobic site on C7 that allows the C7 to insert into the phospholipid bilayer of the pathogen.

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112936 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079105 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.


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