In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene.[7]
^Tonkin E, Hagan DM, Li W, Strachan T (Oct 2002). "Identification and characterisation of novel mammalian homologues of Drosophila polyhomeoticpermits new insights into relationships between members of the polyhomeotic family". Human Genetics. 111 (4–5): 435–42. doi:10.1007/s00439-002-0814-3. PMID12384788. S2CID22192470.
^ abRual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID16189514. S2CID4427026.
Gunther M, Laithier M, Brison O (Jul 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Molecular and Cellular Biochemistry. 210 (1–2): 131–42. doi:10.1023/A:1007177623283. PMID10976766. S2CID1339642.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID16169070. S2CID8235923.
one of the main factors intervening in plant vernalization. PRC1 PRC2 PHC1 PHC2 Heterochromatin protein 1 (Cbx) BMI1 PCGF1, KDM2B PCGF2 (Polycomb group RING
independent of p38. MAPKAPK2 has been shown to interact with: AKT1, MAPK14, PHC2, and SHC1. RIPK1 GRCh38: Ensembl release 89: ENSG00000162889 – Ensembl, May
development of Alzheimer's disease. BMI1 has been shown to interact with: PHC1, PHC2, RING1, and ZBTB16, List of intestinal stem cell marker genes GRCh38: Ensembl
humans is encoded by the MCRS1 gene. MCRS1 has been shown to interact with PHC2, Death associated protein 6, NOL1, PINX1 and Telomerase reverse transcriptase
cases of primary microcephaly. PHC1 has been shown to interact with BMI1 and PHC2. GRCh38: Ensembl release 89: ENSG00000111752 – Ensembl, May 2017 GRCm38:
whorls. The encoded protein has protein-protein interactions with RAB2A, PHC2, NDUFAF8, NDUFS5, COX6B1, ECSIT, NDUFAF4, and COA3. GRCh38: Ensembl release
