This article is about phenapthazine, a pH indicator dye; not to be confused with Nitazene.
Nitrazine
Names
IUPAC name
(3E)-3-[(2,4-Dinitrophenyl)hydrazono]-4-oxonaphthalene-2,7-disulfonic acid
Other names
Nitrazine yellow; Phenaphthazine
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C16H10N4O11S2/c21-16-11-3-2-10(32(26,27)28)5-8(11)6-14(33(29,30)31)15(16)18-17-12-4-1-9(19(22)23)7-13(12)20(24)25/h1-7,17H,(H,26,27,28)(H,29,30,31)/b18-15- checkY
    Key: IHRSXGONVFFQQF-SDXDJHTJSA-N checkY
  • InChI=1/C16H10N4O11S2/c21-16-11-3-2-10(32(26,27)28)5-8(11)6-14(33(29,30)31)15(16)18-17-12-4-1-9(19(22)23)7-13(12)20(24)25/h1-7,17H,(H,26,27,28)(H,29,30,31)/b18-15-
    Key: IHRSXGONVFFQQF-SDXDJHTJBN
  • [O-][N+](=O)c1ccc(c([N+]([O-])=O)c1)N/N=C3/C(=C\c2c(ccc(c2)S(=O)(=O)O)C3=O)S(=O)(=O)O
Properties
C16H10N4O11S2
Molar mass 498.40 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

Nitrazine or phenaphthazine is a pH indicator dye often used in medicine. More sensitive than litmus, nitrazine indicates pH in the range of 4.5 to 7.5. Nitrazine is usually used as the disodium salt.

Use

edit
Nitrazine (pH indicator)
below pH 4.5 above pH 7.5
4.5 ⇌ 7.5
  • This test is done to ascertain the nature of fluid in the vagina during pregnancy especially when premature rupture of membranes (PROM) is suspect. This test involves putting a drop of fluid obtained from the vagina onto paper strips containing nitrazine dye. The strips change color depending on the pH of the fluid. The strips will turn blue if the pH is greater than 6.0. A blue strip means it's more likely the membranes have ruptured.

This test, however, can produce false positives. If blood gets in the sample or if there is an infection present, the pH of the vaginal fluid may be higher than normal. Semen also has a higher pH, so recent vaginal intercourse can produce a false reading.

References

edit
  1. ^ "Point-of-Care Testing, Fecal pH Measurement". Archived from the original on 2007-07-03.

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Rupture of membranes

and nitrazine paper test may be used. An arborization test assesses the patient's vaginal secretions, while a nitrazone paper test uses the nitrazine paper

Amniotic fluid

in pregnancy. Other tests for detecting amniotic fluid mainly include nitrazine paper test and fern test. One main test that is performed on amniotic

Fecal pH test

antibiotics. At least half a milliliter of feces is collected, and a strip of nitrazine paper is dipped in the sample and compared against a color scale. A pH

Prelabor rupture of membranes

performs a valsalva maneuver. Nitrazine test: A sterile cotton swab is used to collect fluid from the vagina and place it on nitrazine (phenaphthazine) paper

PH indicator

and reddish brown under alkaline conditions Chromophore Fecal pH test Nitrazine Sulfarsazene Universal indicator Harris, Daniel C. (2005). Exploring chemical

Kidney stone disease

calcium phosphate crystallization. Testing the urine periodically with nitrazine paper can help to ensure the urine pH remains in this optimal range. Using

Discrimination against drug addicts

know are contaminated (laced) with other substances, such as fentanyl, nitrazine, or xylazine. This is a significant problem, with the DEA reporting fentanyl-related