CD59，亦稱為「膜攻擊複合物（MAC）抑制蛋白」（MAC-inhibitory protein, MAC-IP）、「膜反应性溶血抑制物」（membrane inhibitor of reactive lysis, MIRL）、「膜攻擊複合物抑制因子」（membrane attack complex inhibitory factor, MACIF）或保護素（protectin）[5]，在人體內是一種由CD59基因編碼的糖蛋白，屬於分化簇（Cluster of Differntiation, CD）的一種[6]。CD59屬於LY6/uPAR/α-神經毒素蛋白家族[7]。 CD59通過糖化肌醇磷脂（GPI）基團錨定在細胞膜上。當補體系統激活並已產生C5b678複合物時，CD59會阻止補體成分C9聚集到上述複合體上，從而阻止膜攻擊複合物（MAC）的形成[8]。同時，細胞也會收到信號，通過胞吞作用攝入CD59-CD9複合物[7]。
能影響GPI基團的突變會引起紅細胞膜上的CD59分子和衰變加速因子（CD55）數量減少，可引發陣發性夜間血紅素尿症[9]。
參見
编辑
參考
编辑- ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000085063 – Ensembl, May 2017
- ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000068686 – Ensembl, 2017年5月
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Cd59糖蛋白的应用. [2018-05-19]. （原始内容存档于2019-02-15）.
- ^ Entrez Gene: CD59 molecule, complement regulatory protein.
- ^ 7.0 7.1 Maio M, Brasoveanu LI, Coral S, Sigalotti L, Lamaj E, Gasparollo A, Visintin A, Altomonte M, Fonsatti E. Structure, distribution, and functional role of protectin (CD59) in complement-susceptibility and in immunotherapy of human malignancies (Review). international journal of oncology. Aug 1998, 13 (2): 305–18. PMID 9664126. doi:10.3892/ijo.13.2.305.
- ^ Huang Y, Qiao F, Abagyan R, Hazard S, Tomlinson S. Defining the CD59-C9 binding interaction. J. Biol. Chem. September 2006, 281 (37): 27398–27404. PMID 16844690. doi:10.1074/jbc.M603690200.
- ^ Parker C, Omine M, Richards S, et al. Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood. 2005, 106 (12): 3699–709 [2018-04-27]. PMC 1895106
. PMID 16051736. doi:10.1182/blood-2005-04-1717. （原始内容存档于2009-09-18）.
- ^ Bohana-Kashtan O, Ziporen L, Donin N, Kraus S, Fishelson Z. Cell signals transduced by complement. Mol. Immunol. July 2004, 41 (6–7): 583–597. PMID 15219997. doi:10.1016/j.molimm.2004.04.007.
拓展閱讀
编辑- Tandon N, Morgan BP, Weetman AP. Expression and function of membrane attack complex inhibitory proteins on thyroid follicular cells. Immunology. 1992, 75 (2): 372–7. PMC 1384722 . PMID 1372592.
- Holmes CH, Simpson KL, Okada H, et al. Complement regulatory proteins at the feto-maternal interface during human placental development: distribution of CD59 by comparison with membrane cofactor protein (CD46) and decay accelerating factor (CD55). Eur. J. Immunol. 1992, 22 (6): 1579–1585. PMID 1376264. doi:10.1002/eji.1830220635.
- Hahn WC, Menu E, Bothwell AL, et al. Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59. Science. 1992, 256 (5065): 1805–1807. PMID 1377404. doi:10.1126/science.1377404.
- Ninomiya H, Sims PJ. The human complement regulatory protein CD59 binds to the alpha-chain of C8 and to the "b"domain of C9. J. Biol. Chem. 1992, 267 (19): 13675–80. PMID 1377690.
- Petranka JG, Fleenor DE, Sykes K, et al. Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein. Proc. Natl. Acad. Sci. U.S.A. 1992, 89 (17): 7876–7879. PMC 49817 . PMID 1381503. doi:10.1073/pnas.89.17.7876.
- Motoyama N, Okada N, Yamashina M, Okada H. Paroxysmal nocturnal hemoglobinuria due to hereditary nucleotide deletion in the HRF20 (CD59) gene. Eur. J. Immunol. 1992, 22 (10): 2669–2673. PMID 1382994. doi:10.1002/eji.1830221029.
- Rooney IA, Morgan BP. Characterization of the membrane attack complex inhibitory protein CD59 antigen on human amniotic cells and in amniotic fluid. Immunology. 1992, 76 (4): 541–7. PMC 1421564 . PMID 1383132.
- Tone M, Walsh LA, Waldmann H. Gene structure of human CD59 and demonstration that discrete mRNAs are generated by alternative polyadenylation. J. Mol. Biol. 1992, 227 (3): 971–976. PMID 1383553. doi:10.1016/0022-2836(92)90239-G.
- Philbrick WM, Palfree RG, Maher SE, et al. The CD59 antigen is a structural homologue of murine Ly-6 antigens but lacks interferon inducibility. Eur. J. Immunol. 1990, 20 (1): 87–92. PMID 1689664. doi:10.1002/eji.1830200113.
- Sawada R, Ohashi K, Anaguchi H, et al. Isolation and expression of the full-length cDNA encoding CD59 antigen of human lymphocytes. DNA Cell Biol. 1990, 9 (3): 213–220. PMID 1692709. doi:10.1089/dna.1990.9.213.
- Yamashina M, Ueda E, Kinoshita T, et al. Inherited complete deficiency of 20-kilodalton homologous restriction factor (CD59) as a cause of paroxysmal nocturnal hemoglobinuria. N. Engl. J. Med. 1990, 323 (17): 1184–1189. PMID 1699124. doi:10.1056/NEJM199010253231707.
- Rooney IA, Morgan BP. Protection of human amniotic epithelial cells (HAEC) from complement-mediated lysis: expression on the cells of three complement inhibitory membrane proteins. Immunology. 1991, 71 (3): 308–11. PMC 1384423 . PMID 1702747.
- Watts MJ, Dankert JR, Morgan EP. Isolation and characterization of a membrane-attack-complex-inhibiting protein present in human serum and other biological fluids. Biochem. J. 1990, 265 (2): 471–7. PMC 1136908 . PMID 2302178.
- Okada H, Nagami Y, Takahashi K, et al. 20 KDa homologous restriction factor of complement resembles T cell activating protein. Biochem. Biophys. Res. Commun. 1989, 162 (3): 1553–1559. PMID 2475111. doi:10.1016/0006-291X(89)90852-8.
- Davies A, Simmons DL, Hale G, et al. CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. J. Exp. Med. 1989, 170 (3): 637–654. PMC 2189447 . PMID 2475570. doi:10.1084/jem.170.3.637.
- Sawada R, Ohashi K, Okano K, et al. Complementary DNA sequence and deduced peptide sequence for CD59/MEM-43 antigen, the human homologue of murine lymphocyte antigen Ly-6C. Nucleic Acids Res. 1989, 17 (16): 6728–6728. PMC 318369 . PMID 2476718. doi:10.1093/nar/17.16.6728.
- Sugita Y, Tobe T, Oda E, et al. Molecular cloning and characterization of MACIF, an inhibitor of membrane channel formation of complement. J. Biochem. 1990, 106 (4): 555–7. PMID 2606909.
- Bora NS, Gobleman CL, Atkinson JP, et al. Differential expression of the complement regulatory proteins in the human eye. Invest. Ophthalmol. Vis. Sci. 1994, 34 (13): 3579–84. PMID 7505007.
- Kieffer B, Driscoll PC, Campbell ID, et al. Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins. Biochemistry. 1994, 33 (15): 4471–4482. PMID 7512825. doi:10.1021/bi00181a006.
- Kennedy SP, Rollins SA, Burton WV, et al. Protection of porcine aortic endothelial cells from complement-mediated cell lysis and activation by recombinant human CD59. Transplantation. 1994, 57 (10): 1494–501. PMID 7515200. doi:10.1097/00007890-199405000-00017.
外部連結
编辑- 醫學主題詞表（MeSH）：CD59+Antigen
- Human CD59 genome location and CD59 gene details page in the UCSC Genome Browser.
