There are two variants of the receptor, each encoded by a separate gene:
CD120a - TNFR1 - TNFR superfamily member 1A
CD120b - TNFR2 - TNFR superfamily member 1B
TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior,[3] and is involved in neurotoxic processes.[4] Elevated levels of TNFR1 has been found in severe mental disorders.[5]
Signaling pathway
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Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps
June 2014. About us, West China Hospital, Sichuan University. http://eng.cd120.com/a/aboutus/ Archived 2013-10-27 at the Wayback Machine "West China School