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Myeloblast with an Auer rod (to the left of the nucleus).

Auer rods (or Auer bodies) are large, crystalline cytoplasmic inclusion bodies sometimes observed in myeloid blast cells during acute myeloid leukemia, acute promyelocytic leukemia, high-grade myelodysplastic syndromes and myeloproliferative disorders. Composed of fused lysosomes and rich in lysosomal enzymes, Auer rods are azurophilic and can resemble needles, commas, diamonds, rectangles, corkscrews, or (rarely) granules.[1]

Eponym

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Although Auer rods are named for American physiologist John Auer,[2] they were first described in 1905 by Canadian physician Thomas McCrae, then at Johns Hopkins Hospital,[3] as Auer himself acknowledged in his 1906 paper. Both McCrae and Auer mistakenly thought that the cells containing the rods were lymphoblasts.[4]

Additional images

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  • Bone marrow aspirate showing acute myeloid leukemia with Auer rods in several blasts
    Bone marrow aspirate showing acute myeloid leukemia with Auer rods in several blasts

References

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  1. ^ Ackerman, G. Adolph (1950). "Microscopic and Histochemical Studies on the Auer Bodies in Leukemic Cells". Blood. 5 (9): 847–863. doi:10.1182/blood.V5.9.847.847. PMID 15434012.
  2. ^ Auer, John (1906). "Some hitherto undescribed structures found in the large lymphocytes of a case of acute leukaemia". American Journal of the Medical Sciences. 131 (6): 1002–1015. doi:10.1097/00000441-190606000-00008. ISSN 0002-9629. S2CID 71853154.
  3. ^ McCrae, Thomas (February 1905). "Acute lymphatic leukaemia with a report of five cases". British Medical Journal. 1 (2304): 404–408. doi:10.1136/bmj.1.2304.404. PMC 2319598. PMID 20761949.
  4. ^ Bain, Barbara (August 2011). "Auer rods or McCrae rods?". American Journal of Hematology. 86 (8): 689. doi:10.1002/ajh.21978. PMID 21761434.
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📚 Artikel Terkait di Wikipedia

John Auer

papers during his career and is credited with the first description of Auer rods. Auer also contributed to the study of anaphylaxis and helped develop modern

Myelodysplastic syndrome

granules) Auer rods – automatically RAEB II (if blast count < 5% in the peripheral blood and < 10% in the bone marrow aspirate); also note Auer rods may be

Faggot cell

leukemia (FAB - M3). These promyelocytes (not blast cells) have numerous Auer rods in the cytoplasm which gives the appearance of a bundle of sticks, from

Auer

Auer may refer to: Auer (surname) Germany Auer (Odenwald), a river in the Hessian Odenwald Auer Bach, a river of North Rhine-Westphalia, tributary of

Acute myeloid leukemia

film may show leukemic blast cells. Inclusions within the cells called Auer rods, when seen, make the diagnosis highly likely. A definitive diagnosis requires

Acute promyelocytic leukemia

characteristic rearrangement. The presence of promyelocytes containing multiple Auer rods (termed faggot cells) on the peripheral blood smear is highly suggestive

Leukemia

prominent nucleoli, and specific, but not mandatory, cytoplasmic inclusions – Auer rods (purple needles). Pronunciation /luːˈkiːmiːə/ Specialty Hematology and

Minimally differentiated acute myeloblastic leukemia

agranular and nonreactive when stained for myeloperoxidase activity, and Auer rods are not seen. The blasts react with antibodies to myeloperoxidase and