Asam niflumat 📖 Wikipedia

Asam niflumat
Data klinis
AHFS/Drugs.com	International Drug Names
Kode ATC	M01AX02 (WHO) M02AA17;
Data farmakokinetika
Waktu paruh eliminasi	2,5 jam
Pengenal
	Nama IUPAC Asam 2-{[3-(trifluorometil)fenol]amino}nikotinat;
Nomor CAS	4394-00-7 ;
PubChem CID	4488;
IUPHAR/BPS	2439;
ChemSpider	4333 ;
UNII	4U5MP5IUD8;
KEGG	D08275 ;
ChEMBL	ChEMBL63323 ;
CompTox Dashboard (EPA)	DTXSID1023368 ;
ECHA InfoCard	100.022.289
Data sifat kimia dan fisik
Rumus	C13H9F3N2O2
Massa molar	282,22 g·mol−1
Model 3D (JSmol)	Gambar interaktif;
Titik leleh	204 °C (399 °F)
	SMILES C1=CC(=CC(=C1)NC2=C(C=CC=N2)C(=O)O)C(F)(F)F;
	InChI InChI=1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20) ; Key:JZFPYUNJRRFVQU-UHFFFAOYSA-N ;
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Asam niflumat adalah obat yang digunakan untuk nyeri sendi dan otot. Ia dikategorikan sebagai penghambat siklooksigenase-2. Dalam biologi eksperimental, ia telah digunakan untuk menghambat saluran klorida.^[2] Ia juga telah dilaporkan bekerja pada saluran NMDA^[3] dan GABA-A^[4] serta memblokir saluran kalsium tipe T.^[5]

Referensi

sunting

^ "Half life". Drug Bank. Diakses tanggal 5 Januari 2024.
^ Knauf PA, Mann NA (Mei 1984). "Use of niflumic acid to determine the nature of the asymmetry of the human erythrocyte anion exchange system". The Journal of General Physiology. 83 (5): 703–25. doi:10.1085/jgp.83.5.703. PMC 2215658. PMID 6736917.
^ Lerma J, Martín del Río R (Februari 1992). "Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex activation". Molecular Pharmacology. 41 (2): 217–22. PMID 1371581.
^ Sinkkonen ST, Mansikkamäki S, Möykkynen T, Lüddens H, Uusi-Oukari M, Korpi ER (September 2003). "Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug". Molecular Pharmacology. 64 (3): 753–63. doi:10.1124/mol.64.3.753. PMID 12920213.
^ Balderas E, Ateaga-Tlecuitl R, Rivera M, Gomora JC, Darszon A (Juni 2012). "Niflumic acid blocks native and recombinant T-type channels". Journal of Cellular Physiology. 227 (6): 2542–55. doi:10.1002/jcp.22992. PMC 4146346. PMID 21898399.

Artikel bertopik obat yang berkaitan dengan sistem muskuloskeletal ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[1] "Half life". Drug Bank. Diakses tanggal 5 Januari 2024.

[2] Knauf PA, Mann NA (Mei 1984). "Use of niflumic acid to determine the nature of the asymmetry of the human erythrocyte anion exchange system". The Journal of General Physiology. 83 (5): 703–25. doi:10.1085/jgp.83.5.703. PMC 2215658. PMID 6736917.

[3] Lerma J, Martín del Río R (Februari 1992). "Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex activation". Molecular Pharmacology. 41 (2): 217–22. PMID 1371581.

[4] Sinkkonen ST, Mansikkamäki S, Möykkynen T, Lüddens H, Uusi-Oukari M, Korpi ER (September 2003). "Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug". Molecular Pharmacology. 64 (3): 753–63. doi:10.1124/mol.64.3.753. PMID 12920213.

[5] Balderas E, Ateaga-Tlecuitl R, Rivera M, Gomora JC, Darszon A (Juni 2012). "Niflumic acid blocks native and recombinant T-type channels". Journal of Cellular Physiology. 227 (6): 2542–55. doi:10.1002/jcp.22992. PMC 4146346. PMID 21898399.

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Asam niflumat 📖 Wikipedia

Referensi

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